For over 30 years of existence, COPPE's Laboratory of Computational Methods in Engineering (LAMCE) has been developing high-level academic and scientific research using high-performance computing applied to data science and environmental modelling. Research and development in the above-mentioned areas of knowledge are performed with a multidisciplinary approach, within the scope of R&D projects in partnership with private companies and government agencies. These projects focus on applications and support to different areas of interest such as energy, environment and health. The use of the computational methods cited together allows integrated environmental analysis, providing spatial and temporal distribution of environmental susceptibility and vulnerability to different factors such as environmental and energy risks, food security, disease and disaster risk. This knowledge is a fundamental foundation in meeting the demands associated with different United Nations SDGs such as those associated with human health. The research activities described are being carried out under the initiative known as AIR CENTRE (aircentre.org).